n.间变，退行性发育

Anaplasia is a characteristic feature of malignant neoplasms, where the abnormal cells lack differentiation.
这是一种恶性肿瘤的特征，其中异常细胞缺乏分化。
In histopathology, anaplasia refers to a loss of normal cell differentiation and appearance in cancer cells.
在病理学中，异形性指的是癌细胞失去正常分化和外观。
The presence of anaplasia indicates a higher grade of malignancy and poorer prognosis for the patient.
异形性的存在表明恶性程度更高，预后对患者不利。
The development of anaplastic carcinoma often involves uncontrolled cell proliferation with disordered growth patterns.
原位癌的发展通常涉及不受控制的细胞增殖和无序的生长模式。
Anaplasia can complicate treatment, as it may respond poorly to standard chemotherapy and radiation therapy regimens.
异形化可能使治疗复杂化，因为它可能对标准化疗和放疗方案反应不佳。
Pathologists must be vigilant for signs of anaplasia when examining tissue samples from suspected cancer patients.
病理学家在检查疑似癌症患者的组织样本时，必须警惕异形化的迹象。
In leukemias, anaplasia can manifest as blast cells with abnormal nuclei, indicating a more aggressive form of the disease.
在白血病中，异形化可能表现为具有异常核的原粒细胞，表明疾病更为侵袭性。
Anaplastic changes in the brain tissue are often associated with neurodegenerative disorders or aggressive forms of gliomas.
脑组织中的异形变化常与神经退行性疾病或侵袭性胶质瘤相关联。
Early detection of anaplasia in breast cancer can lead to more targeted and effective treatment strategies.
早期发现乳腺癌中的异形化有助于制定更精准和有效的治疗方案。
The presence of anaplasia in a tumor biopsy suggests that the cancer has progressed beyond its initial stage and may require more aggressive treatment.
活检中发现异形化意味着癌症已经超越了初期阶段，可能需要更激进的治疗。