n.抗代谢物；代谢拮抗物

Antimetabolites are a class of drugs that mimic the structure of natural metabolic compounds to interfere with their function in cells.
Chemotherapy often includes the use of antimetabolites, which target rapidly dividing cancer cells by blocking essential cellular processes.
The primary mechanism of action for antimetabolites is to inhibit DNA synthesis, leading to cell death in cancer.
Methotrexate, a well-known antimetabolite, is commonly used in the treatment of various types of leukemia.
Some antimetabolites, like 5-fluorouracil, have been modified to improve their selectivity and reduce side effects.
Researchers are constantly exploring new antimetabolites as potential therapies for resistant cancer strains.
In pharmacogenetics, understanding how individuals metabolize antimetabolites helps tailor treatments to minimize adverse reactions.
The efficacy of antimetabolites can be monitored through blood tests that measure the levels of the drug and its active metabolites.
Due to their ability to disrupt cellular metabolism, antimetabolites can also be used in combination with radiation therapy for enhanced treatment outcomes.
Proper patient education is crucial when prescribing antimetabolites, as they often require strict adherence to dosing schedules and potential monitoring for side effects.