The
corepressor protein SMRT interacts with nuclear hormone receptors to inhibit transcription.
核心抑制蛋白SMRT与核激素受体相互作用,以抑制转录过程。
In the absence of ligand, the receptor recruits a
corepressor complex to repress gene expression.
在没有配体存在时,受体招募核心抑制复合体来抑制基因表达。
Histone deacetylases (HDACs) often function as part of a larger
corepressor complex in gene silencing.
组蛋白去乙酰化酶(HDACs)在基因沉默过程中常作为较大核心抑制复合体的一部分发挥作用。
CoREST is a known
corepressor that plays a role in epigenetic regulation by modifying chromatin structure.
CoREST是一个已知的核心抑制因子,通过改变染色质结构在表观遗传调控中发挥作用。
Upon binding to unliganded nuclear receptors, NCoR acts as a
corepressor to repress target gene transcription.
当结合到未配体结合的核受体时,NCoR作为核心抑制因子,抑制目标基因的转录。
The addition of a
corepressor can switch a transcription factor from an activator to a repressor.
添加核心抑制因子可以使一个转录因子从激活剂转变为抑制剂。
The
corepressor C-terminal binding protein (CtBP) binds to specific DNA sequences and suppresses gene activation.
核心抑制因子C端结合蛋白(CtBP)结合特定DNA序列并抑制基因激活。
Loss or mutation of certain
corepressors may lead to uncontrolled cell growth and contribute to tumorigenesis.
某些核心抑制因子的丢失或突变可能导致细胞生长失控,并促进肿瘤的发生。
TRIM28, also known as KAP1, serves as a scaffold for assembling various
corepressor complexes on DNA.
TRIM28(也称为KAP1)作为支架,在DNA上组装各种核心抑制复合体。
The recruitment of HDAC-containing
corepressor complexes is crucial for maintaining proper gene repression during development.
招募包含HDAC的核心抑制复合体对于在发育过程中保持正常基因抑制至关重要。
未经许可,严禁转发。QQ交流群:688169419