亲环素

Cyclophilin is a ubiquitous protein that binds to cyclosporine A, playing a crucial role in its immunosuppressive effect.
环孢素是一种普遍存在的蛋白质，它与环孢素A结合，在其免疫抑制效应中起着关键作用。
The peptidyl-prolyl isomerase activity of cyclophilin is involved in various cellular processes such as protein folding and trafficking.
环孢素的肽基脯氨酰异构酶活性参与了诸如蛋白质折叠和转运等各种细胞过程。
Cyclophilin inhibitors have been explored as potential treatments for diseases like HIV, hepatitis C, and cancer due to their ability to modulate immune responses.
由于环孢素抑制剂能够调节免疫反应，因此被探索作为治疗HIV、丙型肝炎和癌症等疾病的可能性药物。
Cyclophilins are found in all kingdoms of life, highlighting their evolutionary conservation and importance across diverse organisms.
环孢素存在于所有生命王国中，突显出它们在不同生物体中的进化保守性和重要性。
Upon binding with cyclophilin, cyclosporine A blocks the transcription factor NFAT, thereby suppressing T-cell activation.
当环孢素与环孢素A结合时，会阻断转录因子NFAT，从而抑制T细胞活化。
Overexpression of certain cyclophilins has been associated with increased metastatic potential in several types of cancer.
某些环孢素的过表达已与多种类型癌症的转移潜能增加相关联。
Cyclophilins can interact with viral proteins, influencing the replication cycle of viruses such as HIV and influenza.
环孢素可以与病毒蛋白相互作用，影响如HIV和流感病毒等的复制周期。
Inhibitors of cyclophilin are being studied for their potential use in organ transplantation to prevent rejection without causing severe side effects.
正在研究环孢素抑制剂在器官移植中的潜在应用，以期在不引起严重副作用的情况下防止排斥反应。
Cyclophilin D, a mitochondrial matrix protein, plays a significant role in regulating the opening of the mitochondrial permeability transition pore.
环孢素D是线粒体基质蛋白，对调控线粒体通透性转换孔的开放起着重要作用。
The discovery of the interaction between cyclophilin and cyclosporine A revolutionized the field of immunosuppression in organ transplantation.
发现环孢素与环孢素A之间的相互作用彻底改变了器官移植领域的免疫抑制研究。