Osteoclasts are multinucleated cells responsible for bone resorption.
破骨细胞是负责骨吸收的多核细胞。
The differentiation of
osteoclasts from hematopoietic stem cells is regulated by various factors.
破骨细胞由造血干细胞分化而来,其过程受到多种因素调控。
In Paget's disease,
osteoclast activity is greatly increased, leading to excessive bone turnover.
在佩吉特病中,破骨细胞活性显著增强,导致骨代谢过度。
Bisphosphonates inhibit the function of
osteoclasts, thus reducing bone loss in patients with osteoporosis.
双磷酸盐抑制破骨细胞功能,从而减少骨质疏松症患者的骨丢失。
Osteoclasts play a crucial role in the remodeling and repair of bone tissue.
破骨细胞在骨骼组织重塑和修复过程中发挥着关键作用。
Activation of
osteoclasts can be triggered by RANKL (Receptor Activator of Nuclear Factor kappa B Ligand).
破骨细胞的激活可由RANKL(核因子κB受体活化剂配体)触发。
The process of bone resorption by
osteoclasts involves the secretion of acid and enzymes that break down the bone matrix.
破骨细胞进行骨吸收的过程包括分泌酸性物质和酶来分解骨基质。
Inhibiting
osteoclastogenesis could be a potential therapeutic strategy for treating bone metastasis in cancer patients.
抑制破骨细胞生成可能是治疗癌症患者骨转移的一种潜在疗法。
Osteoclasts express tartrate-resistant acid phosphatase (TRAP), which is often used as a marker for identifying these cells.
破骨细胞表达抗酒石酸酸性磷酸酶(TRAP),这常被用作识别这类细胞的标志物。
During tooth eruption,
osteoclasts help to clear away the alveolar bone overlying the erupting tooth.
在牙齿萌出过程中,破骨细胞有助于清除即将萌出牙齿上方覆盖的牙槽骨。
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