Phenacetin was once a widely used analgesic and antipyretic drug.
翻译:苯乙酰胺曾经是一种广泛应用的镇痛和解热药物。
Phenacetin is metabolized in the body to form acetaminophen, which is also known as paracetamol.
翻译:苯乙酰胺在体内代谢生成对乙酰氨基酚,也被称为扑热息痛。
Due to its potential side effects,
phenacetin has been withdrawn from the market in many countries.
翻译:由于其潜在的副作用,苯乙酰胺已在许多国家被撤市。
Long-term use of
phenacetin has been linked to renal papillary necrosis and cancer of the urinary bladder.
翻译:长期使用苯乙酰胺与肾乳头坏死和膀胱癌有关。
Phenacetin's primary mechanism of action involves inhibition of prostaglandin synthesis.
翻译:苯乙酰胺的主要作用机制涉及前列腺素合成的抑制。
In the early 20th century,
phenacetin was commonly included in various over-the-counter pain relief formulations.
翻译:在20世纪初,苯乙酰胺通常包含在各种非处方止痛药配方中。
The combination of aspirin,
phenacetin, and caffeine was once marketed under the brand name APC.
翻译:阿司匹林、苯乙酰胺和咖啡因的组合曾以APC品牌名在市场上销售。
Although no longer prescribed,
phenacetin continues to be studied for its pharmacological properties.
翻译:尽管苯乙酰胺不再被处方使用,但其药理性质仍在继续研究中。
Phenacetin may cause adverse reactions when taken concurrently with alcohol or other central nervous system depressants.
翻译:苯乙酰胺与酒精或其他中枢神经系统抑制剂同时服用时可能会引起不良反应。
Following concerns about its safety profile,
phenacetin was replaced by safer alternatives like acetaminophen in most medical treatments.
翻译:出于对其安全性问题的关注,在大多数医疗治疗中,苯乙酰胺已被像对乙酰氨基酚这样更安全的替代品取代。
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