Phosphatidylinositol is a key component of cell membranes and plays an important role in signal transduction pathways.
磷脂酰肌醇是细胞膜的重要组成部分,在信号传导通路中起着重要作用。
The enzyme
phosphatidylinositol 3-kinase (PI3K) phosphorylates
phosphatidylinositol, thereby regulating various cellular processes.
磷脂酰肌醇3-激酶(PI3K)是一种能够磷酸化磷脂酰肌醇的酶,从而调节多种细胞过程。
Phosphatidylinositol 4,5-bisphosphate (PIP2) serves as a precursor for the production of other signaling molecules like inositol triphosphate (IP3) and diacylglycerol (DAG).
磷脂酰肌醇4,5-二磷酸(PIP2)作为生产其他信号分子如肌醇三磷酸(IP3)和二酰甘油(DAG)的前体。
Upon stimulation,
phosphatidylinositol is cleaved by phospholipase C to generate second messengers that trigger intracellular responses.
受到刺激时,磷脂酰肌醇会被磷脂酶C裂解,生成触发细胞内反应的第二信使。
Phosphatidylinositols have been implicated in several cellular functions including vesicle trafficking and cytoskeleton rearrangement.
磷脂酰肌醇涉及多种细胞功能,包括囊泡运输和细胞骨架重排。
Mutations in genes encoding proteins involved in
phosphatidylinositol metabolism can lead to various diseases and disorders.
编码参与磷脂酰肌醇代谢蛋白质的基因突变可能导致各种疾病和障碍。
The breakdown of
phosphatidylinositol into IP3 and DAG leads to calcium release from intracellular stores and activation of protein kinases respectively.
磷脂酰肌醇分解为IP3和DAG,分别导致细胞内钙离子释放和蛋白激酶激活。
Researchers are investigating the therapeutic potential of targeting
phosphatidylinositol signaling pathways in cancer treatment.
研究人员正在研究针对磷脂酰肌醇信号通路在癌症治疗中的潜在治疗价值。
Phosphatidylinositol anchors serve as a means to attach certain proteins to the cell membrane without passing through the entire lipid bilayer.
磷脂酰肌醇锚定物作为一种方式,使得某些蛋白质无需通过整个脂质双层就能附着于细胞膜上。
Inositol phosphate generated from
phosphatidylinositol is essential for proper functioning of neurotransmitter release and glucose homeostasis.
由磷脂酰肌醇产生的肌醇磷酸对于神经递质释放和葡萄糖稳态的正常运作至关重要。
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