塞尔平

Serpins are a family of protease inhibitors found in various organisms, playing a crucial role in regulating proteolysis.
蛋白酶抑制剂（serpins）是各种生物体中发现的一类蛋白质，对蛋白水解过程有重要调控作用。
The most well-known serpin is probably alpha-1 antitrypsin, which protects the lungs from damage by inhibiting trypsin.
最为人所知的serpin可能是α-1抗胰蛋白酶，它通过抑制胰蛋白酶保护肺部免受损伤。
In the bloodstream, serpins like plasminogen activator inhibitor-1 (PAI-1) help prevent excessive blood clot formation.
血液中的如纤溶酶原激活抑制剂-1（PAI-1）这样的serpin有助于防止血栓过度形成。
Some serpins have been implicated in neurodegenerative diseases, such as Alzheimer's and Parkinson's, due to their role in protein aggregation.
一些serpin被认为与神经退行性疾病（如阿尔茨海默病和帕金森病）有关，因为它们在蛋白聚集过程中发挥作用。
Research on serpins has led to the development of novel therapeutic strategies for treating thrombosis and other diseases.
关于serpin的研究已经推动了治疗血栓和其他疾病的新疗法开发。
A mutation in the SERPINA1 gene can result in hereditary emphysema, highlighting the importance of serpins in lung function.
SERPINA1基因突变可能导致遗传性肺气肿，这显示了serpin在肺功能中的关键作用。
The structure of serpins is characterized by a unique mechanism of inhibition, known as suicide substrate inhibition.
serpin的结构以其独特的自杀底物抑制机制为特征。
Serpins are often found in multi-domain proteins, with each domain contributing to their inhibitory activity.
serpin通常存在于多域蛋白中，每个域都对它们的抑制活性有所贡献。
Inhibiting specific serpins has shown promise in cancer therapy, as it can disrupt the balance of proteolytic enzymes involved in tumor growth.
抑制特定的serpin在癌症疗法中显示出潜力，因为它可以破坏参与肿瘤生长的蛋白水解酶平衡。
Proteomics studies are shedding light on the diverse roles serpins play within cells and their involvement in various biological processes.
蛋白质组学研究正在揭示serpin在细胞内的多种作用及其在不同生物学过程中的参与。