The prothrombin time test measures the extrinsic pathway of coagulation by adding tissue
thromboplastin to a sample of blood.
凝血酶原时间测试通过向血液样本中添加组织凝血活酶来测定凝血的外源性途径。
Tissue
thromboplastin is an essential component in the process of blood clotting, also known as the coagulation cascade.
组织凝血活酶是血液凝固(也称为凝血瀑布)过程中必不可少的组成部分。
Thromboplastin, derived from damaged cells, interacts with factor VII to activate factor X, initiating the conversion of prothrombin to thrombin.
来自损伤细胞的凝血活酶与因子VII相互作用以激活因子X,从而启动凝血酶原转化为凝血酶的过程。
In the presence of calcium ions and
thromboplastin, platelets aggregate and fibrinogen is converted into fibrin, leading to clot formation.
在钙离子和凝血活酶的存在下,血小板聚集,纤维蛋白原转化为纤维蛋白,从而形成血栓。
During surgery, monitoring the patient's
thromboplastin time helps assess their hemostatic function and the risk of bleeding.
手术期间监测患者的凝血活酶时间有助于评估其止血功能及出血风险。
Thromboplastin generation in endothelial cells plays a critical role in the initiation of thrombus formation at the site of vascular injury.
内皮细胞产生的凝血活酶在血管损伤部位血栓形成起始阶段发挥关键作用。
Exogenous
thromboplastin can be used as a reagent in laboratory tests for assessing a patient's ability to form clots properly.
外源性凝血活酶可作为实验室试剂用于评估患者正常形成血栓的能力。
Thromboplastin activity varies among different tissues, which can affect the accuracy of international normalized ratio (INR) measurements.
不同组织中的凝血活酶活性存在差异,这可能影响国际标准化比值(INR)测量的准确性。
Purified
thromboplastin extracted from placental tissue is commonly used in diagnostic assays for evaluating anticoagulant therapy.
从胎盘组织提取并纯化的凝血活酶常被用于评估抗凝治疗效果的诊断试验中。
Patients with disseminated intravascular coagulation often exhibit prolonged
thromboplastin times due to consumption of coagulation factors.
分布性血管内凝血(DIC)的患者由于凝血因子消耗往往表现出延长的凝血活酶时间。
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