恶病质

Cachectin, also known as tumor necrosis factor alpha (TNF-α), is a pro-inflammatory cytokine that plays a central role in the immune response.
瘦素，又称为肿瘤坏死因子α（TNF-α），是一种在免疫反应中起核心作用的促炎细胞因子。
The release of cachectin from macrophages can lead to systemic inflammation and weight loss in severe infections or chronic diseases.
巨噬细胞释放的瘦素可能导致严重感染或慢性疾病时的全身性炎症和体重减轻。
Researchers found that blocking cachectin activity could be a potential therapeutic strategy for treating sepsis and certain inflammatory conditions.
研究人员发现阻断瘦素活性可能是治疗败血症和某些炎症性疾病的潜在策略。
High levels of cachectin have been associated with the development of insulin resistance and type 2 diabetes.
瘦素水平升高与胰岛素抵抗及2型糖尿病的发生有关。
In animal models, overexpression of cachectin has been shown to induce anorexia and wasting syndrome.
在动物模型中，瘦素的过度表达已被证明可以引发厌食症和消瘦综合征。
Cachectin is secreted by activated macrophages, monocytes, and T lymphocytes upon encountering pathogens or endotoxins.
遇到病原体或内毒素时，激活的巨噬细胞、单核细胞和T淋巴细胞会分泌瘦素。
Anti-cachectin therapies may help alleviate symptoms in patients with rheumatoid arthritis by suppressing chronic inflammation.
抗瘦素疗法通过抑制慢性炎症可能有助于缓解类风湿关节炎患者的症状。
Cachectin triggers the production of other pro-inflammatory cytokines, amplifying the body's inflammatory response.
瘦素触发其他促炎细胞因子的产生，放大了机体的炎症反应。
Studies have demonstrated that cachectin contributes to the breakdown of muscle tissue in cancer cachexia.
研究已经表明，瘦素在癌症恶病质导致肌肉组织分解的过程中起到一定作用。
The discovery of cachectin's role in inflammation has led to the development of TNF inhibitors, which are now used to treat various autoimmune diseases.
对瘦素在炎症中作用的发现引领了TNF抑制剂的发展，这些药物现已被用于治疗多种自身免疫疾病。