The illness is believed to be caused by a defective
gene.
人们认为这种疾病是由基因缺陷引起的。
Why this similarity exists in smell
genes is difficult to explain, for now.
嗅觉基因中存在这种相似性的原因现在很难解释。
Firms are now studying how
genes interact, looking for correlations that might be used to determine the causes of disease or predict a drug's efficacy.
一些公司正在研究基因如何相互作用，寻找可用来确定病因或者预测药效的某些相关性。
BEIJING — A group of Chinese researchers has created a gene target therapy drug for amyotrophic lateral sclerosis, or ALS.
北京——一组中国研究人员开发了一种针对肌萎缩侧索硬化症（ALS）的基因靶向治疗药物。
SineuGene Therapeutics, a biopharmaceutical company, successfully completed a clinical drug delivery attempt of adeno-associated virus vector gene therapy for ALS.
生物制药公司SineuGene Therapeutics成功完成了腺相关病毒载体基因治疗ALS的临床药物递送尝试。
Cell and gene therapy is a potential future business for Beijing.
细胞和基因治疗是北京未来的一项潜在业务。
"At the University of Queensland in Australia, Robert Henry, professor of innovation in agriculture, and his team are using gene sequencing technology from BGI Group to conduct species cultivation research on macadamia nuts, also known as "Australian nuts", to shorten crop growth time and increase yield.
“在澳大利亚昆士兰大学，农业创新教授Robert Henry和他的团队正在利用华大基因集团的基因测序技术，对澳大利亚坚果（也称为“澳大利亚坚果”）进行物种培育研究，以缩短作物生长时间，提高产量。
Takeda announced an exclusive agreement last week with Shanghai-based Belief BioMed Inc to accelerate the commercialization of an innovative gene therapy for hemophilia type B in the Chinese market.
武田上周宣布与总部位于上海的Believe BioMed Inc达成独家协议，以加快B型血友病创新基因疗法在中国市场的商业化。
Cytiva's 2023 Global Biopharma Resilience Index, a survey of 1,250 biopharma and pharma executives in 22 countries, showed that 59 percent of respondents in China believe the country is somewhat adapted to supporting the rollout of personalized medicines and cell and gene therapies.
Cytiva的2023年全球生物制药弹性指数对22个国家的1250名生物制药和制药高管进行了调查，结果显示，59%的中国受访者认为中国在一定程度上适应了支持个性化药物以及细胞和基因疗法的推出。
"In addition to the acquisition of Alexion, which specializes in rare disease therapies, in 2020, AstraZeneca announced the acquisition of LogicBio Therapeutics, which had a leading position in the development of gene delivery and gene editing and was committed to tackling various rare and serious diseases afflicting children and adults," said Hu.
胡表示：“除了收购专门从事罕见病治疗的Alexion外，阿斯利康还在2020年宣布收购LogicBio Therapeutics，该公司在基因递送和基因编辑领域处于领先地位，致力于解决困扰儿童和成人的各种罕见病和严重疾病。”。
With investment expected to total HK$100 million ($12.76 million) in the next five years, the international R&D center features a 7,000-square-feet high-throughput Next Generation Sequencing gene testing laboratory in accordance with the highest international standards.
预计未来五年投资总额将达1亿港元（1276万美元），该国际研发中心拥有一个7000平方英尺的高通量下一代测序基因检测实验室，符合最高国际标准。
The screening institute will be the first scientific research organization in China that focuses on cutting-edge technological innovations in the early screening of cancer, and is committed to breakthroughs in the research and development of gene multi-dimensional genomics to accelerate the application and practice of screening technology.
筛查机构将是国内首家专注于癌症早期筛查前沿技术创新的科研机构，致力于突破基因多维基因组学的研发，加快筛查技术的应用和实践。
The division also received milestone payments via its cell and gene therapy (C>) and chemoproteomics platforms.
该部门还通过其细胞和基因治疗（C>）以及化学蛋白质组学平台获得了里程碑式的付款。
"NovaSeq X Plus will serve as a new benchmark in the field of genome sequencing, opening up broad application prospects for gene sequencing in China," Li said.
李说：“NovaSeq X Plus将成为基因组测序领域的新标杆，为基因测序在中国的应用开辟广阔前景。”。
For the first time, the study found that 64 percent of Chinese cancer patients had a clinically druggable gene mutation.
这项研究首次发现，64%的中国癌症患者有临床上可药用的基因突变。
For years, Jala gathered thousands of bacteria, fungi and other organisms from natural resources in the Himalayas, and by gene sequencing, the group developed a special strain bank.
多年来，贾拉从喜马拉雅山的自然资源中收集了数千种细菌、真菌和其他生物，通过基因测序，该小组开发了一个特殊的菌株库。
On May 24, it announced that a nucleic acid test kit for detecting hepatitis B, hepatitis C and HIV developed by Sanway Gene, its wholly owned subsidiary, had received certification from a European Union Notified Body, marking the fourth Conformite Europeenne (CE) certification obtained by Sansure Biotech for List A products following the certification of three other products on May 20.
5月24日，该公司宣布，其全资子公司三威基因开发的一种用于检测乙型肝炎、丙型肝炎和艾滋病毒的核酸检测试剂盒已获得欧盟公告机构的认证，这标志着继5月20日其他三种产品获得认证后，三威生物技术公司第四次获得a级产品的符合欧洲标准（CE）认证。
"We are leveraging the potential of gene editing in the fields of both healthcare and agriculture.
“我们正在利用基因编辑在医疗保健和农业领域的潜力。
We've already begun the process to align our global systems, processes, and capabilities to offer world-class solutions to customers working on all bioproduction platforms, including monoclonal antibodies, cell and gene therapies, and mRNA, and supports both therapy and vaccine manufacturing including COVID-19 in China," Wang added.
王补充道：“我们已经开始调整我们的全球系统、流程和能力，为在所有生物生产平台上工作的客户提供世界级的解决方案，包括单克隆抗体、细胞和基因疗法以及mRNA，并支持治疗和疫苗生产，包括中国的新冠肺炎。”。
Since 2011, the US company has completed close to 30 transactions in China, and would continue to deploy capital in digitalization, molecular diagnostics, bioprocessing and bioproduction to help pharmaceutical and biopharmaceutical companies discover, develop and manufacture drugs, and gene and cell therapy to provide individualized therapeutic treatment in an efficient way.
自2011年以来，这家美国公司已在中国完成了近30笔交易，并将继续在数字化、分子诊断、生物加工和生物生产方面部署资金，帮助制药和生物制药公司发现、开发和制造药物，以及基因和细胞治疗，以高效的方式提供个性化治疗。
The company is also showcasing the NextSeq 2000, a gene sequencing platform that won the Red Dot Design Award this year.
该公司还展示了NextSeq 2000，这是一个基因测序平台，今年获得了红点设计奖。
The company said it will continue to leverage high-throughput gene sequencing technology to empower China's healthcare system, improve molecular detection capabilities in hospitals and contribute to the development of precision medicines.
Jointly established by Chinese electronics giant TCL Technology and time-honored Brazilian home appliance manufacturer SEMP in 2016, SEMP TCL had a win-win pattern embedded in its gene from day one.
One major measure of precision medicine is gene sequencing－a detective technology to spot the genes that result in cancer and other diseases.
"During the process of gene sequencing, we acquire great amounts of genomic information, which doesn't specifically target one certain drug and satisfy pharmaceutical companies' various needs, such as the expansion of oncology drug indications, and the applicability for patients," he said.
Global research company MarketsandMarkets estimated the global market of high-throughput gene sequencing will surge from $7.8 billion in 2019 to $24.4 billion in 2025, with a compound annual growth rate of 20.9 percent.
"In terms of gene sequencing, foreign companies started a few years earlier.
Industry experts said in future competition, technology that offers thorough gene detection will be the mainstream.
From advancing gene editing technologies and discovering unique ways to treat the most challenging diseases to enabling the intelligence of electronic devices – our company is everywhere.
"With AskBio and BlueRock Therapeutics, we are building a platform for cell and gene therapy and are further consolidating our emerging leadership in this highly promising and fast-growing field," explained Baumann.
Berry Oncology, a subsidiary of China's leading gene sequencing company, announced Monday findings of a clinical research it initiated got published on Cell Research, marking a milestone in its development of a so-called HIFI tumor testing technology used in the research on early detection of liver cancer in cirrhotic patients.
"Such an adjustment is also viable thanks to WeChat's strong social gene that sets itself apart from rival services like Douyin or Kuaishou.
"Novartis is showcasing innovative medicines, breakthrough cell and gene therapies, and a pipeline of products that it plans to bring to China in the near future.
Founded in 2015, EdiGene has established four gene editing based platforms and is advancing its early stage programs into clinical development for patients with genetic diseases and cancer.
Wang Minchuan, partner of 3H Health Investment, said as one of the most disruptive biomedical technologies, gene editing is rapidly moving toward clinics globally, and EdiGene is leading the wave in China.
Wang said his firm looks forward to contributing its clinical, business and policy resources to further strengthen the company’s capabilities, and is confident EdiGene is well-positioned to be a leader in gene editing therapeutics.
Wei Wensheng, scientific founder of EdiGene, said together with the investors, the company looks forward to translating cutting-edge gene editing technologies into innovative therapies, bringing hope and health to patients and their families.
From traditional clotting factor replacement therapy to innovative gene therapy, the treatment model for hemophilia is constantly developing.
"Science and technology are the gene and an important strategy for Ant," according to a company statement originally in Chinese.
The National Vaccine and Serum Institute, an affiliate of CNBG that is developing a genetically engineered vaccine for the virus, has completed the gene sequence synthesis, and is taking the next steps, including construction of a recombinant plasmid and selection of engineering bacteria.
The National Vaccine & Serum Institute, an affiliate to CNBG that is developing a genetically engineered vaccine for the virus, has completed the gene sequence synthesis, and is taking the next steps including construction of recombinant plasmid and selection of engineering bacteria.
A supporting tumor gene detection kit for the system has also been successfully developed, which can be adapted to many types of samples from tissues to body fluids, including glioma, lung, urothelial, breast and thyroid cancers, covering the fields of early screening, molecular pathology diagnosis and medication guidance, the company said.
GenScript, a Nanjing-based gene synthesis provider, announced on Tuesday collaboration with Harvard University to provide research support to the latter on an ultra-safe cell project, in a bid to benefit Chinese patients as well as others around the globe.
Gene Munster, managing partner with Loup Ventures and a longtime Apple watcher, said the card's adoption is likely to be low in the first year, but it could generate about $1.4 billion of high-margin revenue by 2023.
The CEO said Novartis is also engaging with Chinese regulators and local partners to bring cell and gene therapies to China, which have been heralded as a breakthrough in treating many intractable illnesses.
"I believe our collaboration with Chinese partners can help China become the leader among the emerging markets in bringing cell and gene therapies to countries," said Narasimhan, who presented a policy paper at the CDF 2019 with a wide range of recommendations to the Chinese government, including the regulatory framework, requirements for the research and applications, as well as the establishment of flexible payment mechanisms and alternative funding models.
The new community, located in the International Electronics Headquarters in Beijing Electronics Zone in Northeast Beijing, has over 1,300 workplaces and already attracted several customers from emerging sectors like gene testing, according to WeWork North China's general manager Conan Quan.
In many biomedical sectors－especially vaccines, gene testing, and immunity therapies－domestic companies have showed world-leading capabilities, and have filed hundreds of clinical trial applications for innovative medicines, he added.
Young, an American geneticist and currently the vice president of academic affairs and head of the genetics laboratory at Rockefeller University, delivered a lecture, "Genes that control sleep and circadian rhythms", during the visit, sharing research findings in gene mutations that lead to delayed sleep phase disorder.
Being a loyal fan of Chinese rock'n' roll bands like Beyond and Tang Dynasty, Tao championed their cause, in the process injecting a youthful musical gene into the Jiangxiaobai brand.
"This is a step in the right direction, but more work remains," said Gene Munster, head of research at brokerage Loup Ventures.
That was despite BGI's statement on Monday that the boy's defects were not included within the range of its gene testing methods.
While a large number of his peers have started to set up their own companies over the past few years, Ai did not find the right time to do so, although he believes that he has the right entrepreneurial gene, in a manner of speaking.
"The parks in these five regions will have different pillar businesses, some of them will focus on developing 3-D printing, surgical robots and medical equipment manufacturing, some will cultivate businesses to conduct research and development for gene therapy and integrated artificial intelligence products, based on their regional economic character," said Li.
Last year, China announced a plan to set up the giant panda national park spanning three provinces -- Sichuan, Shaanxi, and Gansu -- to help the endangered animals move around and strengthen their gene pool, which will allow ease of movement for pandas currently living in isolated areas on six mountains in the provinces.
Collaborating with local stakeholders to drive innovationMerck has been working closely with academic institutions, including Peking University, Tsinghua University and Gene Research Institutions, where we provide them with consumables, sophisticated lab equipment and technical know-how.
According to Li, biopharmaceuticals, precision medicine, medical instruments and gene technology will become hot investment and development areas in the healthcare industry in the future.
Precision medicine, he said, is not simply gene sequencing but personalized therapy that uses different treatment protocols for different patients, a method that helps improve the efficiency of diagnosis and treatment.
To provide reproductive products and devices for women having difficulties in conceiving, it requires medicine, lab devices, gene analysis, pure lab water and a total solution.
"The other thing is that Philadelphia is starting to think of itself as a biotech hub, part of the reason is that there are academic centers for gene therapy, and there's academic expertise (here in the area)," he added.
The company provides a range of research services, from biologics－like gene therapy, which is the manipulation of missing or defective cells to correct genetic disorders－to supporting the development of medical device products, such as testing for material and product efficiency.
Touting an internet gene, the Guangzhou-headquartered carmaker has executives from a band of internet players such as Tencent, Alibaba, Huawei and UC Web, according to the company.
A researcher uses a pipette to develop an assay to detect a specific gene of corn at a lab in the Syngenta Biotech Center in Beijing.
WuXi NextCODE, a contract genomics company headquartered in Shanghai, announced on Tuesday that it received a $75 million capital injection, as China targets precision medicine using gene sequencing as a new focus for improving health and medical standards.
Ideally, gene sequencing can enable doctors to use a person's genome and physiology to determine the best treatments for a disease.
Gene research is not only an effective way to prevent birth defects and discover genetic diseases in their early stages.
A researcher uses a pipette to develop method to detect specific gene of corn at a lab in Syngenta Biotech Center in Beijing.
Meanwhile, one newly added prohibited technology items pertains to human cell cloning and gene editing techniques.
We continue to pay attention to the process of incorporating targeted tumor drugs into the national essential medicines list — including gene testing for targeted tumor therapy added to national medical insurance, further optimization of China's medical policies on assisted reproduction, institutionalized thyroid screening for women of childbearing age and digital whole-course diabetes management.
Most recently, the State Council released a document outlining opinions on further optimizing the foreign investment environment and increasing foreign investment, which includes several provisions relevant to the healthcare sector, such as encouraging foreign-invested enterprises to conduct clinical trials of cell and gene therapy drugs that have already been listed overseas within China.
Healthcare companies should seek breakthroughs in terms of cell and gene therapy, said Zhang.
China will support private companies taking the lead in major scientific and technological projects in the fields of industrial software, cloud computing, artificial intelligence, industrial internet, gene and cell medical care, and new energy storage, according to the National Development and Reform Commission on Tuesday.
Shan Zefeng, head of the district and also a deputy to the National People's Congress, said that in the next three years, the area — which is regarded as the industrial engine of the city — will build 10 industrial clusters for the bio-manufacturing, cell and gene treatment, brain science and intelligent medicine sectors.
They will jointly develop and market testing kits for patients with thyroid cancer and lung cancer who have mutation in the RET gene for accurate diagnosis and treatment.
Efforts will be made in the Hainan Boao Lecheng International Medical Tourism Pilot Zone to introduce and cultivate a batch of high-end and professional medical institutions to promote the research progress on stem cell, immune cell and gene therapy, plus other new techniques in the biomedical sector.
Silver Fern Farms, New Zealand's leading producer and exporter of premium quality beef, lamb and venison, shared that "learning mode" inherent in the CIIE gene.
The city's innovation capabilities in artificial intelligence, gene sequencing, new energy vehicles and drones are already at the forefront globally.
These industries will mainly be focused in fields of the most advanced technologies and industrial transformation, such as brain-like intelligence, quantum information, gene technology, future internet, and hydrogen and energy storage.
The 8 billion yuan investment industrial base will focus on antibodies, vaccines, cell therapy and gene therapy.
Local authorities are pushing forward the establishment of organizations such as an international marine development bank, a national deep-sea exploration center, a national deep-sea gene bank and a global think tank on marine affairs, he said.
Takeda's booth also features five innovative products for hemophilia, including a gene therapy that provides diverse treatment options for patients with various types of hemophilia and distinct treatment requirements.
Biomedical plan focuses on research, demo centers, innovation bases, firmsShanghai's municipal government said on Monday it aims to promote gene therapy in a big way.
The city will build five clinical medical research centers and demonstration research hospital wards, and 20 gene therapy innovation bases and platforms by 2025.
Also, 15 backbone enterprises in gene therapy will be set up, according to the Shanghai Action Plan for Promoting Gene Therapy Science and Technology Innovation and Industrial Development (2023-25).
"The Zhangjiang Cell and Gene Industrial Park in Pudong New Area and Pujiang Gene Future Valley in Minhang district will be the main powerhouses to fulfill the goals," he said.
Data from the Shanghai Municipal Commission of Economy and Informatization showed that the city has continued to maintain a good trend in biomedical innovation, especially gene therapy, in recent years.
Twenty of them were in the field of cell and gene therapy.
Part of the larger goal is to speed up the construction and operations of foreign-invested biomedicine projects and encourage foreign-funded enterprises to carry out clinical trials of overseas marketed cell and gene therapy medicines on the Chinese mainland, in accordance with the law.
It focuses on the scientific research needs in key areas such as drug research and development, gene research, biological breeding, and new material research and development.
Innovation is the innate gene of internet companies and product and service innovation in consumption and business scenarios are well worth expecting in a post-pandemic era, the report said citing Blackrock's opinion.
"In the past three years, the industry has developed from 'me-first' and 'me-better' to 'first-in-class' and grasped the latest trends and global hot topic of cell and gene therapy," he added.
According to Wu, cutting-edge industrial clusters engaged in the future businesses of healthcare, smart business, energy, space and materials will be cultivated in the coming decade, and frontier fields of brain-computer interface, gene and cell therapy, intelligent computing, 6G technology, new energy storage and high performance composite materials will be planned.
"Looking forward to the coming decade, cutting-edge industrial clusters engaged in future-oriented businesses in healthcare, smart business, energy, space and new materials will be cultivated, and frontier fields like brain-computer interface, gene and cell therapy, intelligent computing, 6G technology, new energy storage and high-performance composite materials will be planned," Wu said.
Crops made with molecular breeding use genetic engineering to evaluate gene function, but they are not classified as genetically modified since the first step in their development is pollination.
"We are also inviting other major national-level deep-sea platforms, covering gene banks, a big data center and an ocean specimen and sample repository, to come to the city to further marine development," Qi added.
According to Wei Dong, CEO of EdiGene, biotech enterprises are growing rapidly in China and their focus is expanding to diverse domains－from small molecule and macromolecule to cell and gene therapies.
"Countries and multinational companies are ramping up efforts to carry out research and development of gene function and genetic diversity while utilizing the crops," Cao said.
The smart voice assistant sector is poised for explosive growth, Jing said, adding that as a force that has defined the screen smart speaker, Xiaodu brings Baidu's world-leading AI technology gene into homes and is developing new, imaginative scenarios.
One major measure of precision medicine is gene sequencing－a technique used by scientific detectives to spot genes that contribute to diseases such as cancer.
The kit uses next-generation sequencing technology to precisely identify the variation of a specific gene in the body.
Drug sector regulatory reforms since 2015 and the regular National Reimbursement Drug List update mechanism starting from 2017 have fostered innovation in the pharmaceutical and biotechnology sector, he said, taking the cutting-edge cell and gene therapy sector as an example.
In the field of gene sequencing, some domestic startups said that their speed of development in overseas markets even outgrew that in the local market.
Domestic gene technology firm Burning Rock, dedicated to R&D of tumor testing, was listed on the Nasdaq last year after its establishment in 2014.