整合素

Integrins are transmembrane receptors that mediate cell adhesion to the extracellular matrix and play a critical role in cellular signaling.
整合素是跨膜受体，介导细胞与细胞外基质的黏附，并在细胞信号传导中发挥关键作用。
Integrins facilitate communication between cells and their environment by transmitting mechanical forces and biochemical signals.
整合素通过传递力学力量和生物化学信号来促进细胞与其环境之间的交流。
The activation of integrins can influence various cellular processes such as migration, proliferation, and differentiation.
整合素的激活可以影响多种细胞过程，如迁移、增殖和分化。
Integrins are heterodimeric proteins composed of an alpha and a beta subunit which recognize distinct ligands.
整合素是由α和β两个亚单位组成的异二聚体蛋白质，能识别不同的配体。
Therapeutic targeting of integrins has been explored for treating conditions like thrombosis, cancer, and inflammatory diseases.
针对整合素的治疗策略已被研究用于治疗血栓形成、癌症和炎症性疾病等病症。
Fibronectin is an extracellular matrix protein that binds to specific integrins on the cell surface.
纤维连接蛋白是一种细胞外基质蛋白，可结合到细胞表面的特定整合素上。
In wound healing, integrins help coordinate the attachment of cells to the provisional matrix and guide tissue remodeling.
在伤口愈合过程中，整合素有助于协调细胞与临时基质的附着并指导组织重塑。
Leukocytes use integrins to adhere to blood vessel walls during extravasation, a key step in inflammation.
白细胞在炎症的关键步骤——血管外渗过程中，利用整合素粘附于血管壁。
Integrin clustering at focal adhesions leads to the recruitment and activation of intracellular signaling molecules.
在焦点黏附部位的整合素聚集会导致细胞内信号分子的募集和激活。
Pharmacological inhibition of certain integrins has been shown to inhibit tumor growth and metastasis in preclinical models.
研究表明，在临床前模型中，抑制某些整合素的药理活性可以抑制肿瘤生长和转移。