The patient's cancer has become
refractory to chemotherapy, meaning it no longer responds to treatment.
病人的癌症已经变得对抗化疗无反应，即不再对治疗产生效果。
The soil in this area is highly
refractory to cultivation, making it difficult for farmers to grow crops.
这个地区的土壤很难耕种，对农作物的生长很抗拒。
The
refractory metal tungsten is used in high-temperature applications due to its exceptional strength and resistance to melting.
高熔点金属钨因其卓越的强度和抗融性，常用于高温应用中。
After several attempts, the engineer finally found a way to make the
refractory material more malleable.
经过多次尝试，工程师终于找到了使难塑材料变得可塑的方法。
The company's financial situation is becoming increasingly
refractory, with no clear path to recovery.
公司的财务状况日益恶化，看不到明显的复苏迹象。
The therapist worked tirelessly to help the patient overcome their
refractory behavior.
顾问费尽心思帮助病人克服他们的顽固行为。
The
refractory period in an electric circuit is the time during which it cannot conduct electricity after a voltage spike.
电路中的恢复期是指电压峰值后电路无法导电的时间段。
The scientists were surprised by the
refractory nature of certain materials under high pressure.
科学家们对某些材料在高压下表现出的难治性感到惊讶。
A
refractory oven is designed to withstand extremely high temperatures without deforming or losing structural integrity.
难治性烤箱设计能承受极高的温度而不变形或丧失结构完整性。
In computer programming, a
refractory loop is one that takes an excessive amount of time to execute, causing performance issues.
在编程中，难以处理的循环是指执行时间过长，导致性能问题的循环。
Professor Zhou Jianfeng, director of the Department of Hematology at Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, together with his team members, has applied the innovative combination of traditional autologous hematopoietic stem-cell transplantation with CAR-T therapy to the treatment of relapsed and refractory lymphoma.
华中科技大学同济医学院同济医院血液科主任周剑锋教授携团队成员，将传统自体造血干细胞移植与CAR-T疗法的创新结合应用于复发难治性淋巴瘤的治疗。
However, R/R DLBCL is still a common clinically challenging problem, especially in patients with refractory relapses that involve the CNS.
然而，R/R-DLBCL仍然是一个常见的临床挑战性问题，尤其是在涉及中枢神经系统的难治性复发患者中。
The medical community is continuing to explore new treatments and strategies, hoping to improve the cure rate, prolong the survival period, and solve refractory recurrence through the application of individualized and precise treatments for different patients.
医学界正在继续探索新的治疗方法和策略，希望通过对不同患者应用个性化和精确的治疗来提高治愈率，延长生存期，解决难治性复发。
The therapy, which was approved by the FDA on Friday, was a breakthrough after years of research and will bring novel treatment solutions for patients, especially those with drug-resistant or refractory conditions and those prone to develop into severe cases.
该疗法于周五获得美国食品药品监督管理局的批准，是经过多年研究后的一项突破，将为患者带来新的治疗方案，尤其是那些具有耐药性或难治性疾病的患者以及那些容易发展为重症的患者。
The drug is indicated as monotherapy for the treatment of adult patients who have relapsed or refractory acute myeloid leukaemia (AML) with a FLT3 mutation.
该药物被指定为单药疗法，用于治疗复发或难治性急性髓系白血病(AML)的成年患者，且患者的FLT3基因存在突变。
I-Mab is also planning to launch Phase 1/2 trials in China among patients with relapsed or refractory acute myeloid leukemia, or myelodysplastic syndrome.
Shanghai Fosun Pharmaceutical Group Co Ltd announced on Sunday its experimental drug ORIN1001 has received fast-track designation from the US Food and Drug Administration for the treatment of patients with relapsed, refractory and metastatic breast cancer, including triple-negative breast cancer, or TNBC.
The new drug is for the treatment of advanced solid tumors and relapsed refractory metastatic breast cancer.
The advanced bioreactor developed by the Chinese team has been applied to refractory organics treatment economically and efficiently, it said.
Notably, maribavir, a groundbreaking treatment for refractory cytomegalovirus infections in adults after undergoing organ or hemopoietic cell transplant, is expected to receive approval in China this year.
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